Oral Communication

Patient reported questionnaires in MS rehabilitation: testing responsiveness and minimal important difference (MID) of the french version of the multiple sclerosis questionnaire for physiotherapists (MSQPT)


a Haute Ecole de Santé Vaud, b Institut für Physiotherapieforschung

Background/objectives The Multiple Sclerosis Questionnaire for Physical Therapists (MSQPT) is a PRO Questionnaire for the evaluation of rehabilitation of persons with multiple sclerosis (MS). The focus of this study is to evaluate the responsiveness and MID of the French Version of the MSQPT.

Methods We used a combined anchor and distribution-based approach with multiple anchors and multiple transition questions. The intervention (n=31) included MSQPT, HAQUAMS, EDSS, 6 meter Timed walking Test, Berg Balance Scale (BBS) and the 6 Minute Walking Test (6MWT). Responsiveness was evaluated using ES, SRM and Modified SRM. The anchor-based and distribution-based estimates (0.33 and 0.5 SD, SEM, MDC90 and MDC95) were calculated. The specificity of the thresholds for change and the correlation between the physical tests and the items and groups of the MSQPT were determined. The relative efficiency between MSQPT and HAQUAMS was estimated.

Results The main ES for deterioration laid between 0.41 and 0.93 and for improvement range from 0.42 to 1.23. The SRM estimates were generally higher than the ES (deterioration 0.89 to 2.14, improvement 1.08 to 2.14). Main Modified SRMs ranged from 0.03 to 0.31 and were acceptable. The specificity of the thresholds for change ranged from 0.25 to 0.83. Comparing responsiveness of the German and French MSQPT, the data was not unambiguous, but in general the differences between estimates were small. The correlations between the BBS and 6MWT and the items and groups of the MSQPT were reasonable to high (0.51 to 0.74). The MSQPT seemed to be more efficient than the HAQUAMS in detecting improvement but less efficient in finding deterioration.

Conclusion Due to the small sample size the significance of this survey is limited. The available evidence indicates that the French MSQPT is a responsive PRO questionnaire, with similar psychometric characteristics as the original MSQPT and with adequate MID that may be used as thresholds for change in the treatment of persons with MS.

Keywords : Multiple Sclerosis, Rehabilitation, Physiotherapy, Patient-Reported Outcome, Questionnaire, Responsiveness