Metabolic syndrome and type 2 diabetes: risk factor screening in Algerian subject with or without diabetic family related
Mme Amira Fatma BENNACERa, Pr. Ghouti KACIMIb, Pr. El Mahdi HAFFAFc, Pr. Brahim OUDJITd, Pr. Elhadj Ahmed KOCEIRa
a équipe de bioénergétique et métabolisme intermédiaire (BMI), laboratoire de biologie et physiologie des organismes (LBPO), Université des sciences et technologies Houari Boumediene (USTHB), b laboratoire de biochimie, hopital central de l'armée (HCA), c service de medecine nucleaire hopital central de l'armée (HCA), d Service de diabétologie , hopital central de l'armée (HCA)
It is described that the type 2 diabetes mellitus pathogenesis is related to several factors. Many studies shown that metabolic syndrome (MetS) is the most important risk factor to diabetes emergency. In Algeria, the epidemiological study estimates at 7.3% the type 2diabetes prevalence.Objectives: the aim of this study is (I) isolate the most important risk factor between the MetS markers; (II) establish the relationship between MetS and type 2 diabetes family.Subjects and methodology: one hundred no diabetic subjects were included in the study related or not to diabetic family: 43 MetS subjects with type 2 diabetes parental (1st group),27 MetS subjects without type 2 diabetes parental (2nd group) and 30 no MetS subjects but with type 2 diabetes parental (3rd group).10 healthy volunteers participated in the study.All research was conducted over 12 months at diabetologia department hospital. Diabetes screening was achieved by Oral glucose tolerance testing (OGTT).Metabolic parameters were determined by spectrophotometry.Insulin by radioimmunoassay. Insulin sensitivity was also assessed by the homeostasis model assessment (HOMA) approach (glucose × insulin/22.5)Results:The fasting glucose was normal in all three groups. In the 1st and the 2nd groups there is a significant hyperinsulinemia and to a lesser extent in the 3rd group (72%, 66% and 57%, respectively).The HOMA model confirms an acute insulin resistance (79%, 75% and 65% increase respectively).Hypertriglyceridemia was observed only in the 2nd group .HDL dyslipidaemia has been identified in women of the 2nd group (<0.39 g/l).Our study seems to confirm that the genetic predisposition to type 2 diabetes is not the only factor, but environmental factors identified by MetS markers are also to considerate. This study has revealed the same metabolic alterations in subjects screened, they have one or more MetS risk factors with or without diabetes family.
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Keywords : type 2 diabetes screening, Type 2 diabetes heredity, insulin resistance, metabolic syndromeretour